New additions to the Collection include talks in a new series ‘Adaptive Clinical Trial Design’, edited by Prof. Yu Shyr. This series examines adaptive clinical trials design and analysis, and covers both theoretical and practical issues encountered in the frequentist and the Bayesian-based framework. There are also new lectures and updates added to several existing series, including the addition of a new lecture on ‘Malaria – changing paradigms’ by Prof. Janet Cox-Singh, and an update of Professor Martin Buck’s lecture on ‘Nucleotide Dependent Functioning of Bacterial Enhancer Binding Proteins, Activators of Sigma54 RNA Polymerase’. This release also includes a talk by Dr. Paul Jennings on ‘Molecular basis of genetic renal diseases’ which discusses the kidney’s role in whole body homeostasis and extra cellular fluid volume regulation as well as genetic defects which can have serious consequences for health. There is also a new lecture from Prof. Michael Young on ‘Translating retinal stem cells’ in which he discusses cell replacement of rods and cones for groups of hereditary diseases causing retinal degeneration.